The 65^th American Society of Hematology (ASH) Annual Meeting is in full swing in San Diego, California, USA. The expert team from GoBroad Healthcare Group has traveled over 10,000 kilometers to showcase their expertise at the conference, delivering the voice of Chinese scholars.

The GoBroad Expert Team at ASH 2023

At this conference, the GoBroad expert team's participation in 15 studies earned selections for presentation at ASH2023, comprising 1 oral presentation, 11 poster presentations, and 3 paper abstracts, once again ascending the global hematological academic stage with distinguished accomplishments.

Of particular note, Project EVOLVE, a international multicenter study in which Director Pan Jing's involved, was also featured at the conference. Led by Nirali N. Shah, M.D., of the Pediatric Oncology branch at the U.S. National Institutes of Health (NIH), this study was collaboratively undertaken with a total of 49 research teams globally. The preliminary findings of the EVOLVE project presented at this ASH annual meeting analyzed clinical data spanning three continents and eight countries. Through the analysis of such a wealth of data and the sharing of clinical experiences among teams, the project provided the largest dataset to date on lineage switch (LS) patients, also shedding light on the unsatisfactory treatment outcomes for LS patients thus far.

As part of the hematology community, the GoBroad team eagerly anticipates more opportunities in the future to exchange knowledge and learn from colleagues both domestically and abroad in the field, jointly advancing the discipline and benefiting hematological disease patients in China and worldwide.

Conference Speech

Abstract No.239

Title: CD7 Chimeric Antigen Receptor T-Cell Therapy Bridging to Allogeneic Hematopoietic Stem Cell Transplantation Remarkably Improved Long-Term Disease-Free Survival in Refractory/Relapsed T-Cell Acute Lymphoblastic Leukemia/Lymphoma

Reporter: Li Zhihui

Authors: Li Zhihui, Zheng Qinlong, Yang Xinjian, Xu Teng, Wang Lei, Wang Xianxuan, Wen Xiaopei, Song Yanzhi, Zhao Yongqiang, Wu Tong (Corresponding Author)

Institution: Beijing GoBroad Boren Hospital, GoBroad Medical Institute of Hematology (Beijing Center)

Poster Presentation

01

Abstract No.1612

Title: Clinical Implications of Germline Predisposition Gene Variants in Patients with Refractory or Relapsed B Acute Lymphoblastic Leukemia

Authors: Zhao Defeng, Lin Yuehui, Zheng Qinlong, Wu Tong, Tong Chunrong (Corresponding Author)

Institution: Beijing GoBroad Boren Hospital, GoBroad Medical Institute of Hematology (Beijing Center)

02

Abstract No.1709

Title: Clinical Features and Therapeutic Evaluation of Central Nervous System Involvement in Pediatric Anaplastic Large Cell Lymphoma

Authors: Yang Xiaomei¹, Yang Jing², Zhang Yonghong³ (Corresponding Author), Li Fu¹ (Corresponding Author)

Institutions: [1] Children's Hospital Affiliated to Shandong University (Jinan Children's Hospital); [2]Beijing Children's Hospital Affiliated to Capital Medical University; [3] Beijing GoBroad Boren Hospital,GoBroad Medical Institute of Hematology (Beijing Center); and 14 other member institutions of the China Net Childhood Lymphoma

03

Abstract No.1746

Title: CAR T-Cell Therapy Provides an Opportunity for Further Consolidation Treatment for Relapsed or Refractory Adult Burkitt Lymphoma Patients

Authors: Liu Rui, Yang Fan, Shi Hui, Ma Lixia, Zheng Peihao, Su Guoai, Feng Shaomei, Guo Yuelu, Xue Fei, Fu Zhonghua, Xu Teng, Deng Biping, Ke Xiaoyan (Corresponding Author), Hu Kai (Corresponding Author)

Institution:Beijing GoBroad Boren Hospital, GoBroad Medical Institute of Hematology (Beijing Center)

04

Abstract No. 3434

Title: Efficacy and Safety of Autologous Stem Cell Transplantation Combined with CAR-T Therapy in Refractory/Relapsed B-Cell Lymphomas

Authors: Ma Li Xia, Dou Yimeng, Liu Rui, Xu Teng, Fu Zhonghua, Yang Fan, Zheng Peihao, Feng Shaomei, Guo Yuelu, Shi Hui, Lei Yang, Deng Biping, Ke Xiaoyan (Corresponding Author), Hu Kai (Corresponding Author)

Institution:Beijing GoBroad Boren Hospital, GoBroad Medical Institute of Hematology (Beijing Center)

05

Abstract No.3480

Title: CAR T-Cell Therapy in Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia/Lymphoma: A Retrospective Study

Authors: Zhao Liping¹, Zhou Qi², Chen Chen², Ling Zhuojun³, Wang Kai³, Wu Fan³, Xu Jinlong³, Duan Jiajia³, Wang Zelin³, Wang Quangang³, Pan Jing³ (Corresponding Author)

Institutions:[1] Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College; [2] GoBroad Clinical Research Center; [3] Beijing GoBroad Boren Hospital, GoBroad Medical Institute of Hematology (Beijing Center)

06

Abstract No.3513

Title: Evaluating the Impact of Cryopreservation of PBMCs on CAR-T Therapy Efficacy and Safety in DLBCL Patients: An Informative Approach to Optimize Manufacturing Strategies

Authors:Xu Teng, Yang Fan, Liu Rui, Fu Zhonghua, Li Na, Ke Xiaoyan, Feng Shaomei, Deng Biping (Corresponding Author), Hu Kai (Corresponding Author)

Institution: Beijing GoBroad Boren Hospital, GoBroad Medical Institute of Hematology (Beijing Center)

07

Abstract No.4202

Title: Project Evolve, Evaluation of Lineage Switch (LS), an International Initiative: Preliminary Results Reveal Dismal Outcomes in Patients with LS

Authors: Sara K. Silbert,M.D.¹, Nirali N. Shah, M.D² (Corresponding Author), Pan Jing³, and 46 other researchers from various countries.

Institution: [1] National Cancer Institute, NIH, Pediatric Oncology Branch P; [2] Pediatric Oncology Branch, National Institutes of Health ; [3] Beijing GoBroad Boren Hospital, GoBroad Medical Institute of Hematology (Beijing Center); and 46 other participating institutions of the EVOLVE project.

08

Abstract No.4489

Title: Clinical Pathology Characteristics of 221 Pediatric Anaplastic Large Cell Lymphoma-3 Years Follow up and Experience from China Net Childhood Lymphoma(CNCL)

Authors: Huang Shuang¹, Yang Xiaomei², Zhang Yonghong³ (Corresponding Author), Yang Jing¹ (Corresponding Author)

Institution:[1]Beijing Children's Hospital Affiliated to Capital Medical University; [2] Children's Hospital Affiliated to Shandong University (Jinan Children’s Hospital); [3] Beijing GoBroad Boren Hospital, GoBroad Medical Institute of Hematology (Beijing Center); and 14 other member institutions of the China Net Childhood Lymphoma .

09

Abstract No.4507

Title: The Mini-Teddi-R Treatment Demonstrated a High Rate of Remission in Patients with DLBCL Involving the CNS Who Had Previously Been Exposed to BTK Inhibitors

Authors: Shi Hui, Yang Fan, Ke Xiaoyan (Corresponding Author), Hu Kai (Corresponding Author)

Institution: Beijing GoBroad Boren Hospital, GoBroad Medical Institute of Hematology (Beijing Center)

10

Abstract NO. 4638

Title: A Compilation of Experiences in Utilizing CAR-T Cell Therapy for Richter’s Transformation

Authors:Feng Shaomei, Xu Teng, Fu Zhonghua, Liu Haidi, Zheng Peihao, Guo Yuelu, Malixia, Shi Hui, Su Guoai, Lei Yang, Liu Rui, Yang Fan, Li Ruiting, Cao Miaomiao, Dou Yimeng, Yang Fan, Wu Tong, Hu Kai (Corresponding Author), Ke Xiaoyan (Corresponding Author)

Institution: Beijing GoBroad Boren Hospital, GoBroad Medical Institute of Hematology (Beijing Center)

11

Abstract No.4953

Title: A Novel Protocol Improves Engraftment in Tαβ+ Cell Depleted Haplo-HSCT for Patients with Thalassemia Major

Authors: Liao Jianyun, Bu Chao-ke, He LAN, He Yuulin, He Jujian, Chen Dan, Lu Bo, Zhang Weiwei, Tang Haoran, Liu Xinrui, Li Chunfu

Institution: Nanfang-Chunfu Children’s Institute of Hematology, GoBroad Medical Institute of Hematology (Guangdong Center)

Abstract

Title: Prognostic Impact of Minimal Disseminated Disease(MDD) and Minimal Residual Disease(MRD) in Chinese Pediatric Patients with ALK-K-Positive Anaplastic Large Cell Lymphoma(ALCL)

Authors:Yang Xinjian, Yang Jing, Li Yang, Li Fu, Yang Xiaomei, Liu Ying, Zhu Qing, Sun Lirong, Jiang Jian, Dai Yunpeng, Guan Guotao, Liu Ansheng, Zheng Mincui, Wu Pan, Wang Jian, Qu Lijun, Zhang Leping, Jia Yueping, Liu Wei, Zhou Jianwen, Zhang Baoxi, Wang Zhujun, Wang Xige, Gao Hui, Zheng Qinlong (Corresponding Author), Zhang Yonghong (Corresponding Author)

Institution: Beijing GoBroad Boren Hospital,GoBroad Medical Institute of Hematology (Beijing Center), and Member Institutions of the China Net Childhood Lymphoma

Title: The Efficacy and Safety of Olverembatinib Combined with Monoclonal Antibodies as Salvage Therapy for RR B ALL with ABL1 Fusion Gene Positive

Authors: Lin Yuehui¹, Xu Yu², Liu Dan¹, Zhao Defeng¹, Xia Yu¹, Zhang Shuai¹, Wu Huiping¹, Yan Hong¹, Li Biyi¹, Zheng Ruyue¹, Tong Chunrong¹ (Corresponding Author)

Institution:[1] Beijing GoBroad Boren Hospital, GoBroad Medical Institute of Hematology (Beijing Center); [2] Linyi People’s Hospital

Title: Assessment of Activities of Daily Living(ADL) Scale can be Used to Predict overall Survival after CAR-T cell Therapy in Elderly People(over 70 Years of Age) with Refractory/Relapsed B-Cell Lymphoma

Authors: Yang Fan, Liu Rui, Fu Zhonghua, Xu Teng, Zheng Peihao, Feng Shaomei, Guo Yuelu, Shi Hui, Malixia, Su Aiguo, Deng Biping, Ke Xiaoyan (Corresponding Author), Hu Kai (Corresponding Author)

Institution: Beijing GoBroad Boren Hospital, GoBroad Medical Institute of Hematology (Beijing Center)

Note: Research achievements are sorted by abstract number