A 64-year-old Russian woman experienced long-term treatment and multiple relapses after being diagnosed with multiple myeloma in 2014. Despite multiple rounds of chemotherapy, her condition deteriorated again in 2023, manifested by severe bone pain, weakness in her lower extremities and even symptoms of high paraplegia which led to inability to walk and incontinence of urine and feces. Upon visiting GHG medical center, she was diagnosed with relapsed or refractory multiple myeloma(RRMM) with extramedullary infiltration and spinal cord compression.

The GHG medial team quickly developed a treatment plan including relief of the spinal cord compression by chemotherapy, followed by mBCMA-CAR-T immunotherapy. The patient's muscle strength and sensation in her lower extremities began to recover slowly after chemotherapy, and her urination and defecation function gradually improved. After CAR-T therapy, the spinal cord function recovered further, with the muscle strength improving to IV+, normal urination and defecation function, and very good partial response(VGPR) as assessed by RRMM after 26 days of treatment.

In February 2024, the patient was discharged from the hospital from being completely wheelchair dependent to being able to walk slowly. The outcome was highly satisfactory to the patient and her family. The team also provided suggestions on rehabilitation and maintenance treatment after discharge to ensure that the patient can better return to normal life later on.