Anan, a girl, was diagnosed with acute lymphoblastic leukemia in 2014 when she was 4 years old,and her condition was stable after multiple courses of chemotherapy for more than 3 years.The patient achieved a response after CAR-T therapy in 2020. She came to GHG medical center for further diagnosis and treatment due to a second relapse of leukemia in 2021.

After reviewing Anan's past medical history and various examination reports, the team proposed chemotherapy first and completed lumbar puncture+intrathecal injection targeting a stable condition. After her condition was initially stable, the team proposed a sequential CAR-T therapy program. The doctor's rich treatment experience and logically clear treatment thoughts gave Anan's family confidence.

She achieved a very good response after CAR-T therapy. Although the effect of CAR-T therapy was currently very good, the team recommended seizing the opportunity to bridge allogeneic hematopoietic stem cell transplant after CAR-T therapy according to the latest clinical research and comprehensive judgment of her condition and explained the new program of TDH in detail. Compared with other transplant programs, TDH had lower requirements for donor matching, faster recovery and fewer complications, especially the success rate of transplant, which gave her family great confidence. After the transplant, both Anan's indicators and mental status were very good. After more than 9 years of fighting with leukemia by chemotherapy, CAR-T, and bridging to allogeneic hematopoietic stem cell transplant after CAR-T therapy, Anan also began to look forward to returning to school after recovery.