Zinaida Aleksandrovna, female, born in 1957, multiple myeloma, myeloma nephropathy.

This is a patient from Russia who was unfortunately diagnosed with light chain multiple myeloma. During her treatment in Russia, she suffered from renal failure and underwent long-term haemodialysis. All available conventional treatments, including chemotherapy, were tried locally, but the patient's disease remained unmanageable.

In the face of this challenge, CAR-T cell therapy, a cutting-edge treatment, offers her new hope. With its expertise and international reputation in the field of CAR-T cell therapy, GHG medical center is the ideal place for patients seeking advanced treatment. Not only is the hospital technologically advanced, but it also has a wide range of target options for CAR-T therapy that enable it to provide patients with personalised treatment plans.

Aleksandrovna's condition was already quite serious when she arrived at the hospital, with bone pain and renal insufficiency making her extremely weak. In order to give the patient the best possible treatment outcome and reduce her financial burden of travelling across the country, the medical team quickly formulated a sequential B-cell maturation antigen (BCMA)-CART and G protein-coupled receptor class C group 5 member D (GPRC5D)-CART treatment plan for her and completed the treatment in just three weeks.

After two weeks, the patient underwent an efficacy assessment, which showed a more than 90% decrease in M protein and significant improvement in urinary light chain level and serological markers, achieving partial remission (PR). There was a mild cytokine release syndrome (CRS) response to the treatment, but the patient was in good overall condition.

Overall, this patient achieved remarkable results from her treatment at GHG medical center. The cutting-edge CAR-T cell therapy technology provided by the hospital, coupled with the deep concern for the patient's life, achieved a major breakthrough in treatment results and brought the patient the possibility of regaining her life. This not only reflects the hospital's expertise in the field of multiple myeloma treatment, but also demonstrates the important role of international medical cooperation in improving the quality of life of patients.