Alina, Russian, Diffuse Large B-cell Lymphoma
2024-11-15One of the most profound sources of joy for a mother is to witness her child's growth and development. This was a sentiment that resonated deeply with Alina, a young Russian mother. However, shortly after Alina became a mother three years ago, she was diagnosed with lymphoma.
In Russia, Alina attempted a multitude of treatments, yet the size of the tumor and the intricacy of the disease resulted in outcomes that fell short of her expectations. Given her strong attachment to her family, Alina ultimately opted to travel to China, where she discovered that the lump she could feel had diminished considerably under the meticulous care of Director Zhang Yajing's team in GoBroad.
Mediastinal diffuse large B-cell lymphoma is prevalent in young adult women. Given that it is a rare and malignant lymphoma, Alina, who was initially far from fully aware of the disease, believed she was adequately prepared. "Although the diagnosis of this disease was unexpected, my family and I promptly accepted it and initiated anti-tumor treatment, which represented a significant transition for me." In Russia, Alina underwent a challenging course of treatment, involving immunotherapy, targeted therapies, antibody-based drugs, hematopoietic stem cell transplants, CAR-T therapy, and other potential options. However, despite these efforts, the tumor load remained unaltered.
"Unfortunately, my doctor informed me that there were no further promising therapies available in Russia at that time." Fortunately, with the assistance of Alina's mother, her infant is thriving, providing her with the resilience to persevere with her treatment.
On imaging, the lesion was observed to be large and confirmed to be highly aggressive. Director Zhang Yajing recalled the scene when Alina arrived at GoBroad and stated, "In order to adjust the tumor microenvironment and enhance the efficacy of treatment for this complex and difficult-to-treat lymphoma, we organized a multidisciplinary expert consultation. Following a comprehensive evaluation, we ultimately adopted a treatment plan of radiotherapy combined with CAR-T therapy."
The new plan was met with Alina's anticipation and the stage of radiotherapy was successfully completed. GoBroad's medical team provided art materials and Alina began to draw with her mother in the room. As many drawings were completed, the infusion of CAR-T treatment soon concluded.
Subsequently, Sofia informed Zhang Yajing, who had come to assess her condition, that she could perceive a reduction in the size of the lump.
"While an evaluation of the CAR-T infusion is not yet due, it is evident that the mass has shrunk and softened, indicating a promising and progressive shrinking trend." Director Zhang Yajing elaborated, "At the time of Alina's initial presentation, her tumor load was notably elevated. Subsequent to our upfront treatment, her condition has demonstrated a favorable trajectory of improvement. Through the individualized plan we have devised for intensive treatment and subsequent long-term maintenance therapy, there is a reasonable expectation that she will eventually achieve complete remission."
The treatment in a foreign country seemed to last an exceptionally long time, but Alina's morale remained high. She expressed her gratitude towards the medical team, noting that they consistently provided her with encouragement, affirming her resilience and determination. She also conveyed her anticipation for the review results, expressing confidence in their success.







